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pentobarbital will reduce the extent or effect of tamoxifen by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will reduce the extent or outcome of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Double brexpiprazole dose around 1-two weeks if a